CV of Jean-Marc REICHHART



Pr. Jean-Marc REICHHART 
University de Strasbourg &
Institut Universitaire de France

Vice-President of National University Comity
for Cell Biology (65)
Member of EMBO
Director of UPR9022 - CNRS
Réponse Immunitaire et Développement chez les Insectes
Institut for Molecular and Cellular Biology
15 rue René Descartes
67084 STRASBOURG Cedex, FRANCE

E-mail : JM.Reichhart@ibmc.u-strasbg.fr
Office      +33 388 417 034
Secretary   +33 388 417 037
Mobile      +33 682 856 983
Fax         +33 388 606 922


     After classical studies in Natural Sciences, I started a PhD in Embryology, working on the growth and differentiation of Mullerian Ducts in the chicken embryo. As was usual at that time, the PhD was followed by a second or State thesis, also in Embryology. In 1985, following several short-term post-doctoral stays, I started a small group on insect immunity together with Daniele Hoffmann in the Endocrinology Laboratory of Jules Hoffmann.
   Since we needed a large insect for our initial biochemical studies, we started our work on the flesh fly Phormia terranovae, closely related to another dipteran insect, Drosophila melanogasterthat we planned to use later for its powerful genetics. I have been working in quite a monolithic fashion on the Drosophila immune system since 1985. The main milestones during this period were:
1987-1988: I spent 18 month at Transgene, one of the first French Biotechnology Companies, where I succeeded in expressing the first insect antimicrobial peptides containing disulfide bridges in a heterologous system. This experience was decisive when we created Entomed SA, a company dedicated to explore the therapeutic potentials of antimicrobial peptides as new antibiotics.
In 1991, my small group was extremely successful and we decided that the whole laboratory, about 40 people, would reorient their projects from ecdysteroid biosynthesis to insect immunity. Shortly later, due to my former studies in Embryology, I was appointed Professor in Developmental Biology. I became interested in the early development of Drosophila that I was teaching.
In 1996, my interests in the mechanisms of early development led me to discover the implication of a signal transduction pathway, the Toll pathway (which was already known for its role in the setting up of the dorsal-ventral axis in the embryo) in the antifungal response of the adult fly (Lemaitre et al., Cell, 1996). This work was the breakthrough that led to the discovery of the human homologs of the Toll receptor, the Toll-Like-Receptors (TLRs) and their implication in the innate immune system.
The mammalian TLRs belong to a family of receptors that recognize directly microbial determinants and activate the immune system. During early embryogenesis, Toll recognizes an endogenous ligand that has to be processed and activated by serine proteases. However, these proteases are not required to activate the fly immune system. Thus an open question was how the Toll receptor is activated in the adult fly. In 1998-1999, during my sabbatical in the Department of Genetics (M. Ashburner, Cambridge, UK), I discovered that a mutation (called “necrotic”) in a serine protease inhibitory protein (a serpin) leads to constitutive activation of the fly immune system (Levashina et al., Science, 1999). This work indicated that serine proteases different from those operating in the embryo regulate the activation of the Toll receptor during the immune response in adult flies. We discovered the receptors (or PeptidoGlycan Recognition Proteins) for microbial infection two years later (Michel et al., Nature, 2001) and showed that they act upstream of the proteases. These molecules act as soluble receptors secreted in the insect open circulatory system and convey activation to insect Toll via serine proteases cascades, a system reminiscent of the mammalian blood coagulation and the complement cascades. We are currently investigating the role of the serine proteases and their regulatory serpins in the innate immune system of the fly. We have started to isolate several of these proteases (Ligoxygakis et al., Science, 2002) and recently, basing our study on an older observation that I had made, we could show that one of the serine proteases can act as a direct sensor for virulent proteases secreted by pathogenic fungi (Gottar et al., Cell, 2006; El Chamy et al., Nature Immunology, 2008).
 
Ph D:
1977 PhD “Growth and Differentiation of the Mullerian tract in the chicken embryo” followed by a French State thesis in Embryology (1983) “Asymmetrical growth of the mullerian ducts in chicken”.
Supervisor: Professor Jean Thiebold, University Louis Pasteur, Strasbourg, France.
   
Postdoctoral and other professional trainings:
1985 Several short-term post-doctoral stays (6 month in the University of North Carolina at Chapel Hill, Professor L. Gilbert)
1987-1988
18 month in the French Biotechnology Company Transgene, SA, Strasbourg, France. Training in Molecular Biology
1998-1999
Sabbatical in the Department of Genetics (M. Ashburner, Cambridge, UK)
   
Positions:
1984-1992
Assistant professor, University Louis Pasteur of Strasbourg
1992-
Full Professor in Developmental Biology, University of Strasbourg


Price:
1995
Pouchard Price of the French Academy of Sciences


Publications of Jean-Marc REICHHART


Titre, Autheur(s)Journal, Références
Insect immunity. Characterization of a family of novel inducible antibacterial proteins from immunized larvae of the dipteran Phormia terranovae and complete amino acid sequence of the predominant member, diptericin A
DIMARCQ JL, KEPPI E, DUNBAR B, LAMBERT J, REICHHART JM, HOFFMANN D, RANKINE SM, FOTHERGILL JE, HOFFMANN JA
Europ. J. Biochem.
1988 : 171 17-22 (01-01-1988)
Abstract

Article complet
Insect immunity. Isolation from immune blood of the Dipteran Phormia terranovae of two novel antibacterial peptides with sequence homology to rabbit lung macrophage bactericidal peptides
LAMBERT J, KEPPI E, DIMARCQ JL, WICKER, C, REICHHART JM, DUNBAR B, LEPAGE P, VAN DORSSELAER A, HOFFMANN JA, FOTHERGILL J, HOFFMANN D
Proc. Nat. Acad. Sci.
1989 : USA 86 262-266 (01-01-1989)
Abstract

Article complet
Insect Immunity. Isolation of cDNA clones corresponding to diptericin, an inducible antibacterial peptide from Phormia terranovae (Diptera). Transcriptional profiles during immunization
REICHHART JM, ESSRICH M, DIMARCQ JL, HOFFMANN D, HOFFMANN JA, LAGUEUX M
Eur. J. Biochem.
1989 : 182 423-427 (01-01-1989)
Abstract

Article complet
L-Canavanine incorporation into vitellogenin and macromolecular conformation.
ROSENTHAL GA, REICHHART JM, HOFFMANN JA
J. Biol. Chem.
1989 : 264, 13693-13696 (01-01-1989)
Abstract

Article complet
Insect Immunity. Expression of the two major inducible antibacterial peptides, defensin and diptericin, in Phormia terranovae.
DIMARCQ JL, ZACHARY D, HOFFMANN JA, HOFFMANN D, REICHHART JM
EMBO J. 9
1990 : n° 8, 2507-2515 (01-01-1990)
Abstract

Article complet
Insect Immunity. Characterization of a Drosophila cDNA encoding a novel member of the diptericin family of immune peptides and expression studies.
WICKER C, REICHHART JM, HOFFMANN D, HULTMARK D, SAMAKOVLIS C, HOFFMANN JA
J. Biol. Chem.
1990 : 265 n° 36 22493-22498 (01-01-1990)
Abstract

Article complet
Determination of disulfide bridges in natural and recombinant insect defensin A.
LEPAGE P, BITSCH F, ROECKLIN D, KEPPI E, DIMARCQ JL, REICHHART JM, HOFFMANN JA, ROITSCH C, VAN DORSSELAER A
Eur. J. Biochem.
1991 : 196 735-742 (01-01-1991)
Abstract

Article complet
Insect Immunity. Isolation from a coleopteran insect of a novel inducible antibacterial peptide and of new members of the insect defensin family.
BULET P, COCIANCICH S, DIMARCQ JL, LAMBERT J, REICHHART JM, HOFFMANN D, HETRU C, HOFFMANN JA
J. Biol. Chem.
1991 : 266 n° 36 24520-24525 (01-01-1991)
Abstract

Article complet
Two-dimensional 1H-NMR study of recombinant insect defensin A in water. Resonance assignments, secondary structure and global folding.
BONMATIN JM, BONNAT JL, GALLET X, VOVELLE F, REICHHART JM, HOFFMANN JA, PTAK M
J. Biol. NMR
1991 : 2 235-256 (01-01-1991)
Abstract

Article complet
Insect Immunity. Developmental and inducible activity of the Drosophila diptericin promoter.
REICHHART JM, MEISTER M, DIMARCQ JL, ZACHARY D, HOFFMANN D, RUIZ C, RICHARDS G, HOFFMANN JA
EMBO J.
1992 : 11 n° 4 1469-1477 (01-01-1992)
Abstract

Article complet
Expression and secretion in yeast of active insect defensin, an inducible antibacterial peptide from the fleshfly Phormia terranovae.
REICHHART JM, PETIT I, LEGRAIN M, DIMARCQ JL, KEPPI E, LECOCQ JP, HOFFMANN JA, ACHSTETTER T
Inv. Reprod. Develop.
1992 : 21 n° 1 15-24 (01-01-1992)
Abstract

Article complet
Insect Immunity. Two 17-bp repeats nesting a kB-related sequence confer inducibility to the diptericin gene and bind a polypeptide in bacteria-challenged Drosophila.
KAPPLER C, MEISTER M, LAGUEUX M, GATEFF E, HOFFMANN JA, REICHHART JM
EMBO J.
1993 : 12 n° 4 1561-1568 (01-01-1993)
Abstract

Article complet
The humoral antibacterial response of Drosophila.
HOFFMANN JA, HETRU C, REICHHART JM
FEBS Lett.
1993 : 325, 63-66 (01-01-1993)
Abstract

Article complet
Expression and nuclear translocation of the rel/NF-kB-related morphogen dorsal during the immune response of Drosophila.
REICHHART JM, GEORGEL P, MEISTER M, LEMAITRE B, KAPPLER C, HOFFMANN JA
C.R. Acad. Sci.
1993 : Paris 316, 1218-1224. (01-01-1993)
Abstract

Article complet
Insect Immunity : the diptericin promoter contains multiple functional regulatory sequences homologous to mammalian acute-phase response elements.
GEORGEL P, MEISTER M, KAPPLER C, LEMAITRE B, REICHHART JM, HOFFMANN JA
BBRC
1993 : 197 508-517 (01-01-1993)
Abstract

Article complet
Insect immunity. A transgenis analysis in Drosophila defines several functional domains in the diptericin promoter
Meister M, Braun A, Kappler C, Reichhart JM and Hoffmann JA.
EMBO J.
1994: 13, 5958-5966. (01-01-1994)
Abstract

Article complet
Characterization and transcriptional profiles of a Drosophila gene encoding an insect defensin. A study in insect immunity.
DIMARCQ JL, HOFFMANN D, MEISTER M, BULET P, LANOT R, REICHHART JM, HOFFMANN JA
Eur. J. Biochem.
1994 : 221 201-209 (01-01-1994)
Abstract

Article complet
Immune Gene expression in Drosophila. In "Phylogenetic Perspectives in Immunity".
MEISTER M, GEORGEL P, LEMAITRE B, KAPPLER C, LAGUEUX M, REICHHART JM, HOFFMANN JA
Ed. by Hoffmann JA, Janeway Ch, Natori S.R.G. Landes Company
1994, Austin, Georgetown (01-01-1994)
Abstract

Article complet
Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila.
LEMAITRE B, MEISTER M, GOVIND S, GEORGEL P, STEWARD R, REICHHART, HOFFMANN JA
EMBO J.
1995 : 14 536-545 (01-01-1995)
Abstract

Article complet
Drosophila immunity. A sequence homologous to mammalian interferon consensus response elements enhances the activity of the diptericin promoter.
GEORGEL P, KAPPLER C, LANGLEY E, GROSS I, NICOLAS E, REICHHART JM, HOFFMANN JA
Nucleic Acids Res.
1995 : 23 1140-1145 (01-01-1995)
Abstract

Article complet
A recessive mutation, immune-deficiency (imd), defines two distinct control pathways in the Drosophila host defense.
LEMAITRE B, KROMER-METZGER E, MICHAUT L, NICOLAS E, MEISTER M, GEORGEL P, REICHHART JM, HOFFMANN JA
Proc. Natl. Acad. Sci. USA
1995 : 92 9465-9469 (01-01-1995)
Abstract

Article complet
Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties.
LEVASHINA E, OHRESSER S, BULET P, REICHHART JM, HETRU C, HOFFMANN JA
Eur. J. Biochem.
1995 : 233 694-700 (01-01-1995)
Abstract

Article complet
Drosophila immunity : a comparative analysis of the Rel proteins dorsal and Dif in the induction of the genes encoding diptericin and cecropin.
GROSS I, GEORGEL P, KAPPLER C, REICHHART JM, HOFFMANN JA
Nucleic Acids Res.
1996 : 24 1238-1245 (01-01-1996)
Abstract

Article complet
Innate immunity in insects.
HOFFMANN JA, REICHHART JM, HETRU C
Current Opinion in Immunology
1996 : 8 8-13 (01-01-1996)
Abstract

Article complet
The dorsoventral regulatory gene cassette spaetzle/toll/cactus controls the potent antifungal response in Drosophila adults.
LEMAITRE B, NICOLAS E, MICHAUT L, REICHHART JM, HOFFMANN JA
Cell
1996 : 86 973-983 (01-01-1996)
Abstract

Article complet
Drosophila immunity.
HOFFMANN JA, REICHHART JM
Trends in Cell Biology
1997 : 7 309-316 (01-01-1997)
Abstract

Article complet
Drosophila host defense : differential induction of antimicrobial peptide genes after infection by various classes of microorganisms.
LEMAITRE B, REICHHART JM, HOFFMANN JA
Proc. Natl. Acad. Sci. USA
1997 : 94 14614-14619 (01-01-1997)
Abstract

Article complet
In vivo regulation of the IkB homologue cactus during the immune response of Drosophila
Nicolas E, Reichhart JM, Hoffmann JA & Lemaitre B
J. Biol. Chem
1998: 273, 10463-10469 (01-01-1998)
Abstract

Article complet
Drosophila Information Service
Reichhart JM & Ferrandon D

1998: 81, 201-202 (01-01-1998)
Abstract

Article complet
Dorsal-B, a splice variant of the Drosophila factor Dorsal, is a novel Rel/NF-kB transcriptional activator
Gross I, Georgel P, Oertel-Buchheit P, Schnarr M & Reichhart JM
Gene
1999: 228, 233-242 (01-01-1999)
Abstract

Article complet
A GFP-drosomycin reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway
Ferrandon D, Jung AC, Criqui MC, Lemaitre B, Uttenweiler-Joseph S, Michaut L, Reichhart JM & Hoffmann JA
EMBO J
1998: 17, 1217-1227 (01-01-1998)
Abstract

Article complet
A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF
Manfruelli P, Reichhart JM, Steward R, Hoffmann JA & Lemaitre B
EMBO J.
1999: 18, 3380-3391 (01-01-1999)
Abstract

Article complet
Constitutive activation of Toll-mediated antifungal defense in serpin-deficient Drosophila
Levashina E, Langley E, Green C, Gubb D, Ashburner M, Hoffmann JA & Reichhart JM
Science
1999: 285 1917-1919 (01-01-1999)
Abstract

Article complet
The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila
Rutschmann S, Jung AC, Hetru C, Reichhart JM, Hoffmann JA & Ferrandon D
Immunity
2000: 12, 569-580 (01-01-2000)
Abstract

Article complet
Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia
Tzou P, Ohresser S, Ferrandon D, Capovilla M, Reichhart JM, Lemaitre B, Hoffmann JA & Imler JL
Immunity
2000: Vol 13, 737-748 (01-01-2000)
Abstract

Article complet
Médecine/Sciences
Reichhart JM & Imler JL
Toll story Mini-Synthèse
2000: Vol 16, 1439-1442 (01-01-2000)
Abstract

Article complet
The necrotic gene in Drosophila corresponds to one of a cluster of three serpin transcripts mapping at 43A1.2
Green C, Levashina E, McKimmie C, Dafforn T, Reichhart JM, Gubb D
Genetics
2000: Vol 156, 1117-1127. (01-01-2000)
Abstract

Article complet
L'immunité innée : de la drosophile à l'homme
Ferrandon D, Hetru C, Reichhart JM & Hoffmann JA
Pour la Science: "Les défenses de l'organisme 8-12"
Dossier Hors-Série, Octobre 2000 (01-10-2000)
Abstract

Article complet
Immunité innée : deux récepteurs pour détecter l'ADN bactérien
Imler JL & Reichhart JM
Médecine/Sciences
2001: Vol 17 (01-01-2001)
Abstract

Article complet
Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis
Georgel P, Naitza S, Kappler C, Ferrandon D, Zachary D, Swimmer C, Kopczynski C, Duyk G, Reichhart JM, Hoffmann JA
Dev. Cell
2001: Vol 1, 503-514 (01-01-2001)
Abstract

Article complet
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
Michel T, Reichhart JM, Hoffmann JA, Royet J
Nature
2001: Vol 414, 756-759. (01-01-2001)
Abstract

Article complet
A genome-wide analysis of immune responses in Drosophila
Irving P, Troxler L, Heuer TS, Belvin M, Kopczynski C, Reichhart JM, Hoffmann JA, Hetru C
Proc. Natl. Acad. Sci. USA
2001: Vol 98, 15119-15224. (11-12-2001)
Abstract

Article complet
Drosophila innate immunity: an evolutionary perspective
Hoffmann JA, Reichhart JM
Nat Immunol.
2002: Vol 3, 121-126. (01-01-2002)
Abstract

Article complet
Constitutive expression of a single antimicrobial peptide can restore wild-type resistance to infection in immunodeficient Drosophila mutants
Tzou P, Reichhart JM, Lemaitre B
Proc. Natl. Acad. Sci. USA
2002: Vol 99, 2152-2157. (01-01-2002)
Abstract

Article complet
Critical evaluation of the role of the Toll-like receptor 18-Wheeler in the host defense of Drosophila
Ligoxygakis P, Bulet P & Reichhart JM
EMBO reports
2002: Vol 3, 666-673 (01-01-2002)
Abstract

Article complet
Activation of Drosophila Toll during fungal infection by a blood serine protease
Ligoxygakis P, Pelte N, Hoffmann J, Reichhart JM
Science
2002: Vol 297, 114-116. (01-01-2002)
Abstract

Article complet
The Drosophila Immune Defense against Gram-Negative Infection Requires the Death Protein dFADD
Naitza S, Rossé C, Kappler C, Georgel P, Belvin M, Gubb D, Camonis J, Hoffmann J, Reichhart JM
Immunity
2002: Vol 17, 575-581 (01-01-2002)
Abstract

Article complet
Immunity-related genes and gene families in Anopheles gambiae
Christophides GK, Zdobnov E, Barillas-Mury C, Birney E, Blandin S, Blass C, Brey PT, Collins FH, Danielli A, Dimopoulos G, Hetru C, Hoa NT, Hoffmann JA, Kanzok SM, Letunic I, Levashina EA, Loukeris TG, Lycett G, Meister S, Michel K, Moita LF, Muller HM, Osta MA, Paskewitz SM, Reichhart JM, Rzhetsky A, Troxler L, Vernick KD, Vlachou D, Volz J, von Mering C, Xu J, Zheng L, Bork P, Kafatos FC
Science
2002: Vol 298, 159-165. (01-01-2002)
Abstract

Article complet
Splice-Activated UAS airpin vector gives complete RNAI knockout of single or double target transcripts in Drosophila melanogaster
Reichhart JM, Ligoxygakis P, Naitza S, Woerfel G, Imler JL, Gubb D
Genesis
2002: Vol 34, 160-164. (01-01-2002)
Abstract

Article complet
A serpin mutant links Toll activation to melanization in the host defence of Drosophila
Ligoxygakis P, Pelte N, Ji C, Leclerc V, Duvic B, Belvin M, Jiang H, Hoffmann JA, Reichhart JM
EMBO J
2002: Vol 21, 6330-6337. (01-01-2002)
Abstract

Article complet
Drosophila necrotic mutations mirror disease-associated variants of human serpins
Green C, Brown G, Daffoen T, Reichhart JM, Morley T, Lomas D & Gubb D
Development
2003: Vol 130, 1473-1478 (01-01-2003)
Abstract

Article complet
Silencing of Toll pathway components by direct injection of double-stranded RNA into Drosophila
Goto A, Blanbin S, Royet J, Reichhart JM, Levashina EA
Nucleic Acids Research
2003: Vol 31, 6619-6623 (01-01-2003)
Abstract

Article complet
TLR5 takes aim at bacterial propeller
Reichhart JM
Nature Immunology
2003: Vol 4, 1159-1160 (01-01-2003)
Abstract

Article complet
A Serpin Regulates Dorso-Ventral Axis Formation in the Drosophila Embryo
Ligoxygakis P, Roth S, Reichhart JM
Current Biology
2003: Vol 13, 1-20 (01-01-2003)
Abstract

Article complet
Detection of peptidoglycans by NOD proteins
Royet J and Reichhart JM
Trends in cell biology
2003: Vol 12, 610-614 (01-01-2003)
Abstract

Article complet
Editorial
Reichhart JM
Mol. Immunol.
2004: Vol 40, 843 (01-01-2004)
Abstract

Article complet
The Immune Response of Drosophila Melanogaster
Leclerc V, Reichhart JM
Immunological Reviews
2004: Vol 198, 59-71. (01-01-2004)
Abstract

Article complet
Cg-Rel, the first Rel/NF-B homolog characterized in a mollusk, the Pacific oyster Crassostrea gigas
Montagnani C, Kappler C, Reichhart JM, Escoubas JM
FEBS Letters
2004: Vol 561, 75-82 (01-01-2004)
Abstract

Article complet
Toll-dependent and Toll-independent immune response in Drosophila
Imler JL, Ferrandon D, Royet J, Reichhart JM, Hetru C, Hoffmann JA
Journal of Endotoxin Research
2004: Vol 10, 241-246 (01-01-2004)
Abstract

Article complet
Sensing and Signaling during Infection in Drosophila
Royet J, Reichhart JM, Hoffmann JA
Current Opinion in Immunology
2005: Vol 17, 11-17 (01-01-2005)
Abstract

Article complet
Evolution and integration of innate immune systems from fruit flies to man: lessons and questions
Martinelli C, Reichhart JM
Journal of Endotoxin Research
2005: Vol 11, 243-8 (01-01-2005)
Abstract

Article complet
Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila
Kocks C, Cho JH, Nehme N, Ulvila J, Pearson AM, Meister M, Strom C, Conto SL, Hetru C, Stuart LM, Stehle T, Hoffmann JA, Reichhart JM, Ferrandon D, Ramet M, Ezekowitz RA
Cell
2005: Vol 123, 335-346 (01-01-2005)
Abstract

Article complet
Tip of another iceberg: Drosophila serpins.
Reichhart JM
Trends in Cell Biology
2005: Vol 123, 335-346 (01-01-2005)
Abstract

Article complet
Immune challenge induces N-terminal cleavage of the Drosophila serpin Necrotic
Pelte N, Robertson AS, Zou Z, Belorgey D, Dafforn TR, Jiang H, Lomas D, Reichhart JM, Gubb D
Insect Biochem. Mol. Biol.
2006: Vol 1, 37-46 (00-01-2006)
Abstract

Article complet
Prophenoloxidase activation is not required for survival to microbial infections in Drosophila
Leclerc V, Pelte N, ElChamy L, Martinelli C, Ligoxygakis P, Hoffmann JA, Reichhart JM
EMBO Reports
2006: Vol 7, 231-235 (31-01-2006)
Abstract

Article complet
Prophenoloxidase activation is not required for survival to microbial infections in Drosophila
Leclerc V, Pelte, N, El Chamy L, Martinelli C, Ligoxygakis P, Hoffmann JA and Reichhart JM
EMBO Rep
2006 : (2):231-5 (17-09-2006)
Abstract

Article complet
Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors
Gottar M, Gobert V, Matskevich AA, Reichhart JM, Wang C, Butt TM, Belvin M, Hoffmann JA, Ferrandon D
Cell
2006: Vol 127, 1425-37. (28-12-2006)
Abstract

Article complet
Drosophila Serpins: Regulatory Cascades in Innate Immunity and Morphogenesis in
Gubb D, Robertson A, Dafforn T, Troxler L, Reichhart JM
Ed. by Silverman GA and Lomas DA, World Scientific Pub., London UK
2007, Chapter 8, p 207-227 (01-01-2007)
Abstract

Article complet
Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in Drosophila and mice
Goto A, Matsushita K, Gesellchen V, El Chamy L, Kuttenkeuler D, Takeuchi O, Hoffmann JA, Akira S, Boutros M, Reichhart JM
Nature Immunology
2008 : Vol 9, 97-104 (01-01-2008)
Abstract

Article complet
Sensing of 'danger signals' and pathogen-associated molecular patterns defines binary signaling pathways 'upstream' of Toll.
El Chamy L, Leclerc V, Caldelari I, Reichhart JM.
Nature Immunology
2008: Vol 10, 1165-70. (24-08-2008)
Abstract

Article complet
Phagocytosis in Drosophila melanogaster Immune Response
Leclerc V, Caldelari I, Veresceaghina N, Reichhart JM
Phagocyte-Pathogen Interactions
D.G. Russell and S. Gordon, ed. ASM Press Washington DC, p 513-521 (01-01-2009)
Abstract

Article complet
Toll-dependent antimicrobial responses in Drosophila larval fat body require Spaetzle secreted by haemocytes.
Shia AK, Glittenberg M, Thompson G, Weber AN, Reichhart JM, Ligoxygakis P.
J Cell Sci.
2009: Vol 122, 4505-15. (24-11-2009)
Abstract

Article complet
Caspase-mediated cleavage, IAP binding, and ubiquitination: linking three mechanisms crucial for Drosophila NF-kappaB signaling.
Paquette N, Broemer M, Aggarwal K, Chen L, Husson M, Erturk-Hasdemir D, Reichhart JM, Meier P, Silverman N.
Mol. Cell
2010: Vol 37, 172-82 (29-01-2010)
Abstract

Article complet
Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions.
Whisstock JC, Silverman GA, Bird PI, Bottomley SP, Kaiserman D, Luke CJ, Pak SC, Reichhart JM, Huntington JA.
J Biol Chem.
2010: Vol 285, 24307-24312 (06-08-2010)
Abstract

Article complet
Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems.
Silverman GA, Whisstock JC, Bottomley SP, Huntington JA, Kaiserman D, Luke CJ, Pak SC, Reichhart JM, Bird PI.
J Biol Chem.
2010: Vol 285, 24299-24305 (06-08-2010)
Abstract

Article complet
Involvement of the cytokine MIF in the snail host immune response to the parasite Schistosoma mansoni.
Baeza Garcia A, Pierce RJ, Gourbal B, Werkmeister E, Colinet D, Reichhart JM, Dissous C, Coustau C.
PLoS Pathog.
2010: Vol 6 (01-09-2010)
Abstract

Article complet
Structure-function analysis of grass clip serine protease involved in Drosophila Toll pathway activation
Christine Kellenberger,?,1 Philippe Leone,? Laurent Coquet,? Thierry Jouenne,? Jean-Marc Reichhart,‖ and Alain Roussel?
J Biol Chem
2011 : 286(14):12300-7 (08-04-2011)
Abstract

Article complet
A tecpr1-dependent selective autophagy pathway targets bacterial pathogens
Michinaga Ogawa, Yuko Yoshikawa, Taira Kobayashi, Hitomi Mimuro, Makoto Fukumatsu, Kotaro Kiga, Zhenzi Piao, Hiroshi Ashida, Mitsutaka Yoshida, Shigeru Kakuta, Tomohiro Koyama, Yoshiyuki Goto, Takahiro Nagatake, Shinya Nagai, Hiroshi Kiyono, Magdalena Kawalec, Jean-Marc Reichhart, Chihiro Sasakawa
Cell Host Microbe
Vol 9, 376-389 (01-05-2011)
Abstract

Article complet
The Drosophila serpins multiple functions in immunity and morphogenesis.
Reichhart JM, Gubb D, Leclerc V
Methods in Enzymology
2011: Vol 499, 205-225 (01-06-2011)
Abstract

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Pathogen-Derived Effectors Trigger Protective Immunity via Activation of the Rac2 Enzyme and the IMD or Rip Kinase Signaling Pathway.
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Immunity
2011 : Vol 35, 536-549 (01-10-2011)
Abstract

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Specific versus Non-Specific Immune Responses in an Invertebrate Species Evidenced by a Comparative de novo Sequencing Study
PLoS One
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Abstract

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Nsango SE, Abate L, Thoma M, Pompon J, Fraiture M, Rademacher A, Berry A, Awono-Ambene PH, Levashina EA, Morlais I.
Int J Parasitol.
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Abstract

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AP-1/Fos-TGase2 axis mediates wounding-induced Plasmodium falciparum killing in Anopheles gambiae.
Nsango SE, Pompon J, Xie T, Rademacher A, Fraiture M, Thoma M, Awono-Ambene PH, Moyou RS, Morlais I, Levashina EA.
J Biol Chem.
2013 Apr 16 (16-04-2013)
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