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UPR 9022 - IBMC : Immune Response and Development in Insects
Français  English 
Jules A. HOFFMANN



HOFFMANN A. Jules
UPR 9022 du CNRS
Molecular and Cellular Biology Institut
15, rue René Descartes
67084 Strasbourg Cedex, FRANCE


E-mail : J.Hoffmann@unistra.fr
Tel : +33 388 41 70 77
     +033 672 66 88 54
Fax : 33 388 60 69 22

 

Distinguished Class Research Director at CNRS (Emeritus) and Group Leader,

Past President of the French National Academy of Sciences (2007—2008)

Invited Professor at Strasbourg University

Member of the American Academy of Arts and Sciences

 

 

Jules Hoffmann was born in Luxembourg and moved for his studies to the University of Strasbourg France, where he received his Ph.D. in Biology in 1969. He has held various positions with the French National Research Agency CNRS, the latest being that of Distinguished Class Research Director and of Member of the Board of Administration of this Agency. He also serves as a Professor for the University of Strasbourg. From 1993 to 2005 he was the Director of the CNRS Institute of Molecular and Cellular Biology in Strasbourg. The research of Jules Hoffmann was continuously centered on studies of the development and the defense reactions of insects. Since 1990, JH and his laboratory have explored the potent antimicrobial mechanisms of Drosophila as a paradigm for innate immune defenses. The group is in particular credited with having unravelled the role of Toll receptors in fighting infections. Jules Hoffmann has authored or co-authored 250 publications and edited several volumes. He is a Member of the French National Academy of Sciences of which he served as Vice-President (2005-06) and President (2007-08). He is a Member of the European Molecular Biology Organization (EMBO) and of the German National Academy of Sciences Leopoldina. Jules Hoffmann is a Foreign Associate of the National Academy of Sciences of the U.S., the American Academy of Arts and Sciences and of the Russian Academy of Sciences. Jules Hoffmann is the recipient of several international awards, namely the William B.Coley Award, the Robert Koch Prize and the Balzan Prize. He is also an awardee of the 2010 Lewis Rosenstiel Price and the 2010 Keio Prize for Medical Sciences. J.Hoffmann and his wife Daniele, his long-time scientific co-worker, have two children who have both embraced academic careers, and four grand-children.
   
Publications


Curriculum Vitae (PDF)




Publications de Jules A. HOFFMANN


Titre, Autheur(s)Journal, Références
AP-1/Fos-TGase2 axis mediates wounding-induced Plasmodium falciparum killing in Anopheles gambiae.
Nsango SE, Pompon J, Xie T, Rademacher A, Fraiture M, Thoma M, Awono-Ambene PH, Moyou RS, Morlais I, Levashina EA.
J Biol Chem.
2013 Apr 16
Abstract

Article complet
Broad RNA interference-mediated antiviral immunity and virus-specific inducible responses in Drosophila.
Kemp C, Mueller S, Goto A, Barbier V, Paro S, Bonnay F, Dostert C, Troxler L, Hetru C, Meignin C, Pfeffer S, Hoffmann JA, Imler JL.
J Immunol.
2013 Jan 15;190(2):650-8
Abstract

Article complet
Genetic clonality of Plasmodium falciparum affects the outcome of infection in Anopheles gambiae.
Nsango SE, Abate L, Thoma M, Pompon J, Fraiture M, Rademacher A, Berry A, Awono-Ambene PH, Levashina EA, Morlais I.
Int J Parasitol.
2012 ? 15;42(6):589-95
Abstract

Article complet
Drosophila EYA regulates the immune response against DNA through an evolutionarily conserved threonine phosphatase motif.
Liu X, Sano T, Guan Y, Nagata S, Hoffmann JA, Fukuyama H
PLoS One.
2012;7(8):e42725
Abstract

Article complet
RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in Drosophila
Mueller S, Gausson V, Vodovar N, Deddouche S, Troxler L, Perot J, Pfeffer S, Hoffmann JA, Saleh MC, Imler JL
Proc Natl Acad Sci USA
2010 Nov 9;107(45):19390-5
Abstract

Article complet
The N-terminal domain of drosophila gram-negative binding protein 3 (GNBP3) defines a novel family of fungal pattern recognition receptors.
Mishima Y, Quintin J, Aimanianda V, Kellenberger C, Coste F, Clavaud C, Hetru C, Hoffmann JA, Latgé JP, Ferrandon D, Roussel A.
Journal of Biological Chemistry.
2009 Oct 16;284(42):28687-97. Epub 2009 Aug 19.
Abstract

Article complet
Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium.
Fraiture M, Baxter RH, Steinert S, Chelliah Y, Frolet C, Quispe-Tintaya W, Hoffmann JA, Blandin SA, Levashina EA.
Cell Host Microbe.
2009 Mar 19;5(3):273-84
Abstract

Article complet
The DEXD/H-box helicase Dicer-2 mediates induction of an antiviral activity in drosophila
Deddouche S., Matt N., Budd A., Mueller S., Kemp C., Galiana-Arnoux D., Dostert C., Antoniewski C., Hoffmann J.A. & Imler J.L.
Nature Immunology
2008: Vol. 9, 1425-1432
Abstract

Article complet
Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in Drosophila and mice
Goto A, Matsushita K, Gesellchen V, El Chamy L, Kuttenkeuler D, Takeuchi O, Hoffmann JA, Akira S, Boutros M, Reichhart JM
Nature Immunology
2008 : Vol 9, 97-104
Abstract

Article complet
A Model of Bacterial Intestinal Infections in Drosophila melanogaster
Nehme NT, Liégeois S, Kele B, Giammarinaro P, Pradel E, Hoffmann J, Ewbank JJ, and Ferrandon D
PloS Pathog
2007:
Abstract

Article complet
The Drosophila systemic immune response : sensing and signalling during bactrial and fungal infections
Ferrandon D, Imler JL, Hetru C, Hoffmann JA
Nature Reviews of Immunology
2007 : Vol 7, 862-874
Abstract

Article complet
Genetic analysis of resistance to viral infection
Beutler B, Eidenschenk C, Crozat K, Imler JL, Takeuchi O, Hoffmann JA, Akira S
Nature Reviews of Immunology
2007 : Vol 7, 753-766
Abstract

Article complet
Antifungal defense in Drosophila
Hoffmann JA
Nature Immunology
2007 : Vol 8, 543-545
Abstract

Article complet
The host defense of Drosophila melanogaster
Lemaitre B, Hoffmann JA
Annual Review of Immunology
2007 : Vol 25, 697-743
Abstract

Article complet
Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors
Gottar M, Gobert V, Matskevich AA, Reichhart JM, Wang C, Butt TM, Belvin M, Hoffmann JA, Ferrandon D
Cell
2006: Vol 127, 1425-37.
Abstract

Article complet
Fz2 and cdc42 mediate melanization and actin polymerization but are dispensable for Plasmodium killing in the mosquito midgut
Shiao SH, Whitten MM, Zachary D, Hoffmann JA, Levashina EA
PLoS Pathog.
2006: Vol 2, 1152-1164
Abstract

Article complet
Boosting NF-κB-Dependent Basal Immunity of Anopheles gambiae Aborts Development of Plasmodium berghei
Frolet C, Thoma M, Blandin S, Hoffmann JA, Levashina EA
Immunity
2006: Vol 25, 677-85.
Abstract

Article complet
Prophenoloxidase activation is not required for survival to microbial infections in Drosophila
Leclerc V, Pelte, N, El Chamy L, Martinelli C, Ligoxygakis P, Hoffmann JA and Reichhart JM
EMBO Rep
2006 : (2):231-5
Abstract

Article complet
Essential function in vivo for Dicer-2 in host defense against RNA viruses in drosophila
Galiana-Arnoux D, Dostert C, Schneemann A, Hoffmann JA, Imler JL
Nature Immunology
2006: Vol 7, 590 - 597
Abstract

Article complet
Prophenoloxidase activation is not required for survival to microbial infections in Drosophila
Leclerc V, Pelte N, ElChamy L, Martinelli C, Ligoxygakis P, Hoffmann JA, Reichhart JM
EMBO Reports
2006: Vol 7, 231-235
Abstract

Article complet
Downregulation of the Drosophila Immune Response by Peptidoglycan-Recognition Proteins SC1 and SC2
Bischoff V, Vignal C, Duvic B, Boneca IG, Hoffmann JA, Royet J
PLoS Pathog
2006: Vol 2, 139-147
Abstract

Article complet
The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of Drosophila
Dostert C, Jouanguy E, Irving P, Troxler L, Galiana-Arnoux D, Hetru C, Hoffmann JA, Imler JL
Nature Immunology
2005: Vol 6, 646-953
Abstract

Article complet
New insights into Drosophila larval hemocyte functions through genome-wide analysis
Irving P, Ubeda JM, Doucet D, Troxler L, Lagueux M, Zachary D, Hoffmann JA, Hetru C, Meister M
Cellular Microbiology
2005: Vol 7, 335-350
Abstract

Article complet
Sensing and Signaling during Infection in Drosophila
Royet J, Reichhart JM, Hoffmann JA
Current Opinion in Immunology
2005: Vol 17, 11-17
Abstract

Article complet
Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila
Kocks C, Cho JH, Nehme N, Ulvila J, Pearson AM, Meister M, Strom C, Conto SL, Hetru C, Stuart LM, Stehle T, Hoffmann JA, Reichhart JM, Ferrandon D, Ramet M, Ezekowitz RA
Cell
2005: Vol 123, 335-346
Abstract

Article complet
Sensing infection in Drosophila: Toll and beyond
Ferrandon D, Imler JL, Hoffmann JA
Semin. Immunol.
2004: Vol 16, 43-53.
Abstract

Article complet
Primitive Immune Systems
Hoffmann JA
Immunological Reviews
2004: Vol 198, 5-9
Abstract

Article complet
Role of Drosophila pattern recognition receptor, PGRP-SD, in detection of Gram-positive bacteria
Bischoff V, Vignal C, Boneca T, Michel T, Hoffmann JA, Royet J
Nature Immunology
2004: Vol 5, 1175-1180
Abstract

Article complet
Toll-dependent and Toll-independent immune response in Drosophila
Imler JL, Ferrandon D, Royet J, Reichhart JM, Hetru C, Hoffmann JA
Journal of Endotoxin Research
2004: Vol 10, 241-246
Abstract

Article complet
Peptidomic and Proteomic Analyses of the Systemic Immune Response of Drosophila
Levy F, Rabel D, Charlet M, Bulet P, Hoffmann JA, Ehret-Sabatier L
Biochimie
2004: Vol 86, 607-616
Abstract

Article complet
Toll signalling: the TIReless quest for specify
Imler JL, Hoffmann J
Nature Immunology
2003: Vol 4, 105-106
Abstract

Article complet
Virulence factors of the human opportunistic pathogen Serratia marcescens identified by in vivo screening
Kurz CL, Chauvet S, Andres E, Aurouze M, Vallet I, Michel GP, UH M, Celli J, Filloux A, DE Bentzmann S, Steinmetz I, Hoffmann JA, Finlay BB, Gorvel JP, Ferrandon D, Ewbank JJ
EMBO J.
2003: Vol 22, 1451-1460
Abstract

Article complet
Drosophila melanogaster antimicrobial defense. In "J. Infectious Disease:Innate Immunity"
Hetru C, Troxler L, Hoffmann JA
Ezekowitz R.A.B. and Hoffmann J.A., eds. Humana Press Inc, Totowa
2003: 187 Suppl 2 :S327-34
Abstract

Article complet
Binding of the Drosophila cytokine Spaetzle to Toll is direct and establishes signaling
Weber AN, Tauszig-Delamasure S, Hoffmann JA, Lelievre E, Gascan H, Ray KP, Morse MA, Imler JL, Gay NJ
Nature Immunology
2003: Vol 4, 794-800
Abstract

Article complet
The Immune Response of Drosophila
Hoffmann JA
Nature
2003: Vol 426, 33-38
Abstract

Article complet
Spheniscins : avian b-defensins in preserved stomach contents of the king penguin, Aptenodytes patagonicus
Thouzeau C, Le Maho Y, Froget G, Sabatier L, Le Bohec C, Hoffmann JA, Bulet P
J. Biol. Chem.
2003: Vol 278, 51053-51058
Abstract

Article complet
Dual activation of the Drosophila toll pathway by two pattern recognition receptors
Gobert V, Gottar M, Matskevich AA, Rutschmann S, Royet J, Belvin M, Hoffmann JA, Ferrandon D
Science
2003: Vol 302, 2126-2130
Abstract

Article complet
Drosophila innate immunity: an evolutionary perspective
Hoffmann JA, Reichhart JM
Nat Immunol.
2002: Vol 3, 121-126.
Abstract

Article complet
Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections
Tauszig-Delamasure S, Bilak H, Capovilla M, Hoffmann JA, Imler JL
Nat Immunol.
2002: Vol 3, 91-97.
Abstract

Article complet
The Drosophila response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein
Gottar M, Gobert V, Michel, T Belvin M, Duyk G, Hoffmann JA, Ferrandon D, Royet J
Nature
2002: Vol 416, 640-644.
Abstract

Article complet
Toll receptors in Drosophila: a family of molecules regulating development and immunity
Imler JL, Hoffmann JA
Current Topic Microbiol. Immunol.
2002: Vol 270, 63-79.
Abstract

Article complet
Activation of Drosophila Toll during fungal infection by a blood serine protease
Ligoxygakis P, Pelte N, Hoffmann J, Reichhart JM
Science
2002: Vol 297, 114-116.
Abstract

Article complet
The Drosophila Immune Defense against Gram-Negative Infection Requires the Death Protein dFADD
Naitza S, Rossé C, Kappler C, Georgel P, Belvin M, Gubb D, Camonis J, Hoffmann J, Reichhart JM
Immunity
2002: Vol 17, 575-581
Abstract

Article complet
Notch Signaling Controls Lineage Specification during Drosophila Larval Hematopoiesis
Duvic B, Hoffmann J, Meister M, Royet J
Current Biology
2002: Vol 12, 1923-1927.
Abstract

Article complet
PVF2, a PDGF/VEGF-like growth factor, induces hemocyte proliferation in Drosophila larvae
Munier A-I, Doucet D, Perrodou E, Zachary D, Meister M, Hoffmann J, Janeway CA, Lagueux M
EMBO Rep.
2002: Vol 3, 1195-1200.
Abstract

Article complet
Immunity-related genes and gene families in Anopheles gambiae
Christophides GK, Zdobnov E, Barillas-Mury C, Birney E, Blandin S, Blass C, Brey PT, Collins FH, Danielli A, Dimopoulos G, Hetru C, Hoa NT, Hoffmann JA, Kanzok SM, Letunic I, Levashina EA, Loukeris TG, Lycett G, Meister S, Michel K, Moita LF, Muller HM, Osta MA, Paskewitz SM, Reichhart JM, Rzhetsky A, Troxler L, Vernick KD, Vlachou D, Volz J, von Mering C, Xu J, Zheng L, Bork P, Kafatos FC
Science
2002: Vol 298, 159-165.
Abstract

Article complet
Tissue and stage-specific expression of the Tolls in Drosophila embryos
Kambris Z, Hoffmann JA, Imler JL, Capovilla M
Gene Expression Patterns
2002: Vol 2, 311-317.
Abstract

Article complet
A serpin mutant links Toll activation to melanization in the host defence of Drosophila
Ligoxygakis P, Pelte N, Ji C, Leclerc V, Duvic B, Belvin M, Jiang H, Hoffmann JA, Reichhart JM
EMBO J
2002: Vol 21, 6330-6337.
Abstract

Article complet
A genome-wide analysis of immune responses in Drosophila
Irving P, Troxler L, Heuer TS, Belvin M, Kopczynski C, Reichhart JM, Hoffmann JA, Hetru C
Proc. Natl. Acad. Sci. USA
2001: Vol 98, 15119-15224.
Abstract

Article complet
Insect Immunity. Constitutive expression of a cysteine-rich antifungal and a linear antibacterial peptide in a termite insect
Lamberty M, Zachary D, Lanot R, Bordereau C, Robert A, Hoffmann JA, Bulet P
J. Biol Chem.
2001: Vol 276, 4085-4092.
Abstract

Article complet
LPS-induced immune response in Drosophila
Imler JL, Tauszig S, Jouanguy E, Forestier C & Hoffmann JA
J. Endotox. Res.
2001: Vol 6, 459-462
Abstract

Article complet
Toll receptors in innate immunity
Imler JL & Hoffmann JA
Trends in Cell Biol
2001: Vol 11, 304-310
Abstract

Article complet
Gambicin: a novel immune responsive antimicrobial peptide from the malaria vector Anopheles gambiae
Vizioli J, Bulet P, Hoffmann JA, Kafatos FC, Muller HM, Dimopoulos G
Proc. Natl. Acad. Sci. USA
2001: Vol 98, 12630-12635.
Abstract

Article complet
Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis
Georgel P, Naitza S, Kappler C, Ferrandon D, Zachary D, Swimmer C, Kopczynski C, Duyk G, Reichhart JM, Hoffmann JA
Dev. Cell
2001: Vol 1, 503-514
Abstract

Article complet
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
Michel T, Reichhart JM, Hoffmann JA, Royet J
Nature
2001: Vol 414, 756-759.
Abstract

Article complet
L'immunité innée : de la drosophile à l'homme
Ferrandon D, Hetru C, Reichhart JM & Hoffmann JA
Pour la Science: "Les défenses de l'organisme 8-12"
Dossier Hors-Série, Octobre 2000
Abstract

Article complet
The antimicrobial host defense of Drosophila
Meister M, Hetru C & Hoffmann JA
Curr. Topics in Microbiol. and Immunol.
2000: 248 17-36
Abstract

Article complet
Signaling mechanisms in the antimicrobial host defense of Drosophila
Imler JL & Hoffmann JA
Curr. Opin. in Microbiol.
2000: 3, 16-22
Abstract

Article complet
Cloning and analysis of a cecropin gene from the malaria vector mosquito, Anopheles gambiae
Vizioli J, Bulet P, Charlet M, Lowenberger C, Blass C, Müller HM, Dimopoulos G, Hoffmann JA, Kafatos FC & Richman A
Insect Mol. Biol.
2000: 9, 75-84
Abstract

Article complet
The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila
Rutschmann S, Jung AC, Hetru C, Reichhart JM, Hoffmann JA & Ferrandon D
Immunity
2000: 12, 569-580
Abstract

Article complet
Androctonin, a hydrophilic disulphide-bridged non-haemolytic antimicrobial peptide : a plausible mode of action
Hetru C, Letellier L, Oren Z, Hoffmann JA & Shai Y
Biochem. J.
2000: 345, 653-664
Abstract

Article complet
The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response
Basset A, Khush RS, Braun A, Gardan L, Boccard F, Hoffmann JA & Lemaitre B
Proc. Natl. Acad. Sci. USA
2000: 97, 3376-3381
Abstract

Article complet
Toll-related receptors and the control of antimicrobial peptide expression in Drosophila
Tauszig S, Jouanguy E, Hoffmann JA & Imler JL
Proc. Natl. Acad. Sci. USA
2000: 97, 10520-10525
Abstract

Article complet
Role of Drosophila IKKg in a Toll-independent antibacterial immune response
Rutschmann S, Jung AC, Zhou R, Silverman N, Hoffmann JA & Ferrandon D
Nature Immunol.
2000: 1, 342-347
Abstract

Article complet
Constitutive expression of a complement-like protein in Toll and JAK gain-of-function mutants of Drosophila
Lagueux M, Perrodou E, Levashina EA, Capovilla & Hoffmann JA
Proc. Natl. Acad. Sci. USA
2000: 97, 11427-11432
Abstract

Article complet
Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia
Tzou P, Ohresser S, Ferrandon D, Capovilla M, Reichhart JM, Lemaitre B, Hoffmann JA & Imler JL
Immunity
2000: Vol 13, 737-748
Abstract

Article complet
Toll and Toll-like proteins : an ancient family of receptors signaling infection
Imler JL & Hoffmann JA
Reviews in Immunogenetics
2000: Vol 2, 294-304
Abstract

Article complet
A microfluometer assay to measure the expression of b-galactosidase and GFP reporter genes in single Drosophila flies
Jung AC, Criqui MC, Rutschmann S, Hoffmann JA & Ferrandon D
Biotechniques
2000: Vol 30, 594-601.
Abstract

Article complet
Mosquito-Plasmodium interactions in response to immune activation of the vector
Lowenberger CA, Kamal S, Chiles J, Paskewitz S, Bulet P, Hoffmann JA & Christensen BM
Exp. Parasitol.
1999: 91, 59-69
Abstract

Article complet
A GFP-drosomycin reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway
Ferrandon D, Jung AC, Criqui MC, Lemaitre B, Uttenweiler-Joseph S, Michaut L, Reichhart JM & Hoffmann JA
EMBO J
1998: 17, 1217-1227
Abstract

Article complet
Phylogenetic perspectives in innate immunity
Hoffmann JA, Kafatos FC, Janeway CA Jr & Ezekowitz RAB
Science
1999: 284, 1313-1318
Abstract

Article complet
A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF
Manfruelli P, Reichhart JM, Steward R, Hoffmann JA & Lemaitre B
EMBO J.
1999: 18, 3380-3391
Abstract

Article complet
Constitutive activation of Toll-mediated antifungal defense in serpin-deficient Drosophila
Levashina E, Langley E, Green C, Gubb D, Ashburner M, Hoffmann JA & Reichhart JM
Science
1999: 285 1917-1919
Abstract

Article complet
A novel insect defensin from the ant Formica rufa
Taguchi S, Bulet P, Hoffmann JA
Biochimie
1998: 80 (4), 343-6
Abstract

Article complet
Antimicrobial peptides from insects, In Molecular Mechanisms of Immune Responses in Insects
Hetru C, Hoffmann D & Bulet P
Eds Brey PT & Hultmark D, Chapman & Hall
1998: pp 40-66
Abstract

Article complet
In vivo regulation of the IkB homologue cactus during the immune response of Drosophila
Nicolas E, Reichhart JM, Hoffmann JA & Lemaitre B
J. Biol. Chem
1998: 273, 10463-10469
Abstract

Article complet
Plasmodium gallinaceum : differential killing of some mosquito stages of the parasite by insect defensin
Shahabuddin M, Fields I, Bulet P, Hoffmann JA & Miller LH
Exp. parasitol
1998: 89, 103-112
Abstract

Article complet
Differential display of peptides during the immune response of Drosophila : a matrix-assisted laser desorption ionization time-of-flight mass spectrometry study
Uttenweiler-Joseph S, Moniatte M, Van Dorsselaer A, Hoffmann JA & Bulet P
Proc. Natl. Acad Sci. USA
1998: 95, 11342-11347
Abstract

Article complet
Analysis of the Drosophila host defense in domino mutant larvae, which are devoid of hemocytes
Braun A, Hoffmann JA & Meister M
Proc. Natl. Acad. Sci. USA
1998: 95, 14337-14342
Abstract

Article complet
Cysteine-rich antimicrobial peptides in invertebrates
Dimarcq JL, Bulet P, Hetru C & Hoffmann JA
Biopolymers (Peptide Science)
1998: 47, 465-477
Abstract

Article complet
Drosophila immunity.
HOFFMANN JA, REICHHART JM
Trends in Cell Biology
1997 : 7 309-316
Abstract

Article complet
Solution structure of drosomycin, the first inducible antifungal protein from insects.
LANDON C, SODANO P, HETRU C, HOFFMANN JA, PTAK M
Protein Science
1997 : 6 1878-1884
Abstract

Article complet
Drosophila host defense : differential induction of antimicrobial peptide genes after infection by various classes of microorganisms.
LEMAITRE B, REICHHART JM, HOFFMANN JA
Proc. Natl. Acad. Sci. USA
1997 : 94 14614-14619
Abstract

Article complet
Treatment of l(2)mbn Drosophila tumorous blood cells with the steroid hormone ecdysone amplifies the inducibitity of antimicrobial peptide gene expression.
DIMARCQ JL, IMLER JL, LANOT R, EZEKOWITZ A, HOFFMANN JA, JANEWAY C & LAGUEUX M (1997).
Insect Biochem. & Molec. Biol.
1997 : 27 877-886
Abstract

Article complet
Drosophila immunity : a comparative analysis of the Rel proteins dorsal and Dif in the induction of the genes encoding diptericin and cecropin.
GROSS I, GEORGEL P, KAPPLER C, REICHHART JM, HOFFMANN JA
Nucleic Acids Res.
1996 : 24 1238-1245
Abstract

Article complet
Innate immunity in insects.
HOFFMANN JA, REICHHART JM, HETRU C
Current Opinion in Immunology
1996 : 8 8-13
Abstract

Article complet
Inducible immune factors of the vector mosquito Anopheles gambiae : biochemical purification of a defensin antibacterial peptide and molecular cloning of preprodefensin cDNA.
RICHMAN A, BULET P, HETRU C, BARILLAS-MURY C, HOFFMANN JA, KAFATOS F
Insect Molec. Biol.
1996 : 5 203-210
Abstract

Article complet
Innate immunity. Isolation of several cystein-rich antimicrobial peptides from the blood of a mollusc, Mytillus edulis.
CHARLET M, CHERNYSH S, PHILIPPE H, HETRU C, HOFFMANN JA, BULET P
J. Biol. Chem.
1996 : 271 21808-21813
Abstract

Article complet
The dorsoventral regulatory gene cassette spaetzle/toll/cactus controls the potent antifungal response in Drosophila adults.
LEMAITRE B, NICOLAS E, MICHAUT L, REICHHART JM, HOFFMANN JA
Cell
1996 : 86 973-983
Abstract

Article complet
Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila.
LEMAITRE B, MEISTER M, GOVIND S, GEORGEL P, STEWARD R, REICHHART, HOFFMANN JA
EMBO J.
1995 : 14 536-545
Abstract

Article complet
Drosophila immunity. A sequence homologous to mammalian interferon consensus response elements enhances the activity of the diptericin promoter.
GEORGEL P, KAPPLER C, LANGLEY E, GROSS I, NICOLAS E, REICHHART JM, HOFFMANN JA
Nucleic Acids Res.
1995 : 23 1140-1145
Abstract

Article complet
Refined three-dimensional solution structure of insect defensin A.
CORNET B, BONMATIN JM, HETRU C, HOFFMANN JA, PTAK M, VOVELLE F
Structure
1995 : 3 435-448
Abstract

Article complet
Insect immunity. The inducible antibacterial peptide diptericin carries two O-glycans necessary for biological activity.
BULET P, HEGY G, LAMBERT J, VAN DORSSELAER A, HOFFMANN JA, HETRU C
Biochemistry
1995 : 34 7394-7400
Abstract

Article complet
A recessive mutation, immune-deficiency (imd), defines two distinct control pathways in the Drosophila host defense.
LEMAITRE B, KROMER-METZGER E, MICHAUT L, NICOLAS E, MEISTER M, GEORGEL P, REICHHART JM, HOFFMANN JA
Proc. Natl. Acad. Sci. USA
1995 : 92 9465-9469
Abstract

Article complet
Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties.
LEVASHINA E, OHRESSER S, BULET P, REICHHART JM, HETRU C, HOFFMANN JA
Eur. J. Biochem.
1995 : 233 694-700
Abstract

Article complet
Insect Immunity : Isolation of three novel inducible antibacterial defensins from the vector mosquito, Aedes aegypti.
LOWENBERGER C, BULET P, CHARLET M, HETRU C, HODGEMAN B, CHRISTENSEN B, HOFFMANN JA
Insect Biochem. Molec. Biol.
1995 : 25 867-873
Abstract

Article complet
Structure-activity analysis of thanatin, a novel 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides.
FEHLBAUM P, BULET P, CHERNYSH S, BRIAND JP, ROUSSEL JP, LETELLIER L, HETRU C, HOFFMANN JA
Proc. Natl. Acad. Sci. USA
1995 : 93 1221-1225
Abstract

Article complet
Insect immunity. A transgenis analysis in Drosophila defines several functional domains in the diptericin promoter
Meister M, Braun A, Kappler C, Reichhart JM and Hoffmann JA.
EMBO J.
1994: 13, 5958-5966.
Abstract

Article complet
Characterization and transcriptional profiles of a Drosophila gene encoding an insect defensin. A study in insect immunity.
DIMARCQ JL, HOFFMANN D, MEISTER M, BULET P, LANOT R, REICHHART JM, HOFFMANN JA
Eur. J. Biochem.
1994 : 221 201-209
Abstract

Article complet
The inducible antibacterial peptides of insects.
COCIANCICH S, BULET P, HETRU C, HOFFMANN JA
Parasitology Today
1994 : 10 n° 4 132-139
Abstract

Article complet
Novel inducible antibacterial peptides from a Hemipteran insect, the sap-sucking bug Pyrrhocoris apterus.
COCIANCICH S, DUPONT A, HEGY G, LANOT R, HOLDER F, HETRU C, HOFFMANN JA, BULET P
Biochem. J.
1994 : 300 567-575
Abstract

Article complet
Antibacterial peptides/polypeptides in the insect host defense. A comparison with vertebrate antibacterial peptides/polypeptides.
HETRU C, BULET P, COCIANCICH S, DIMARCQ JL, HOFFMANN D, HOFFMANN JA
Ed. by Hoffmann JA, Janeway Ch, Natori S.R.G. Landes Company.
1994, Austin, Georgetown
Abstract

Article complet
Immune Gene expression in Drosophila. In "Phylogenetic Perspectives in Immunity".
MEISTER M, GEORGEL P, LEMAITRE B, KAPPLER C, LAGUEUX M, REICHHART JM, HOFFMANN JA
Ed. by Hoffmann JA, Janeway Ch, Natori S.R.G. Landes Company
1994, Austin, Georgetown
Abstract

Article complet
Septic injury of Drosophila induces the synthesis of a potent antifungal peptide with sequence homology to plant antifungal peptides.
FEHLBAUM P, BULET P, MICHAUT L, LAGUEUX M, BROEKAERT W, HETRU C, HOFFMANN JA
J. Biol. Chem.
1994 : 269 33159-33163
Abstract

Article complet
A novel inducible antibacterial peptide of Drosophila carries an O-glycosylated substitution.
BULET P, DIMARCQ JL, HETRU C, LAGUEUX M, CHARLES M, HEGY G, VAN DORSSELAER A, HOFFMANN JA
J. Biol. Chem.
1993 : 268 14893-14897
Abstract

Article complet
The humoral antibacterial response of Drosophila.
HOFFMANN JA, HETRU C, REICHHART JM
FEBS Lett.
1993 : 325, 63-66
Abstract

Article complet
Insect defensin, an inducible antibacterial peptide, forms voltage-dependent channels in Micrococcus luteus.
COCIANCICH S, GHAZI A, HETRU C, HOFFMANN JA, LETELLIER L
J. Biol. Chem.
1993 : 268, 19239-19245
Abstract

Article complet
Expression and nuclear translocation of the rel/NF-kB-related morphogen dorsal during the immune response of Drosophila.
REICHHART JM, GEORGEL P, MEISTER M, LEMAITRE B, KAPPLER C, HOFFMANN JA
C.R. Acad. Sci.
1993 : Paris 316, 1218-1224.
Abstract

Article complet
Insect Immunity : the diptericin promoter contains multiple functional regulatory sequences homologous to mammalian acute-phase response elements.
GEORGEL P, MEISTER M, KAPPLER C, LEMAITRE B, REICHHART JM, HOFFMANN JA
BBRC
1993 : 197 508-517
Abstract

Article complet
Insect Immunity. Developmental and inducible activity of the Drosophila diptericin promoter.
REICHHART JM, MEISTER M, DIMARCQ JL, ZACHARY D, HOFFMANN D, RUIZ C, RICHARDS G, HOFFMANN JA
EMBO J.
1992 : 11 n° 4 1469-1477
Abstract

Article complet
Expression and secretion in yeast of active insect defensin, an inducible antibacterial peptide from the fleshfly Phormia terranovae.
REICHHART JM, PETIT I, LEGRAIN M, DIMARCQ JL, KEPPI E, LECOCQ JP, HOFFMANN JA, ACHSTETTER T
Inv. Reprod. Develop.
1992 : 21 n° 1 15-24
Abstract

Article complet
A novel insect defensin mediates the inducible antibacterial activity in larvae of the dragonfly Aeschna cyanea (Paleoptera, Odonata).
BULET P, COCIANCICH S, REULAND M, SAUBER F, BISCHOFF R, HEGY G, VAN DORSSELAER A, HETRU C, HOFFMANN JA
Eur. J. Biochem.
1992 : 209 977-984
Abstract

Article complet
Insect defensins, inducible antibacterial peptides of the insect host defence.
HOFFMANN JA, HETRU C
Immunol. Today
1992 : 13 n° 10 411-415
Abstract

Article complet
Insect Immunity. Two 17-bp repeats nesting a kB-related sequence confer inducibility to the diptericin gene and bind a polypeptide in bacteria-challenged Drosophila.
KAPPLER C, MEISTER M, LAGUEUX M, GATEFF E, HOFFMANN JA, REICHHART JM
EMBO J.
1993 : 12 n° 4 1561-1568
Abstract

Article complet
Synthesis of a tritiated 3-dehydroecdysteroid putative precursor of ecdysteroid biosynthesis in Locusta migratoria.
DOLLE F, HETRU C, ROUSSEL JP, ROUSSEAU B, SOBRIO F, LUU B, HOFFMANN JA
Tetrahedron
1991 : 47 7067-7080
Abstract

Article complet
Isolation and structural characterization of an insulin-related molecule, a predominant neuropeptide from Locusta migratoria (Insecta, Orthoptera)
HETRU C, LI KW, BULET P, LAGUEUX M, HOFFMANN JA
Eur. J. Biochem.
1991 : 201 495-499
Abstract

Article complet
Determination of disulfide bridges in natural and recombinant insect defensin A.
LEPAGE P, BITSCH F, ROECKLIN D, KEPPI E, DIMARCQ JL, REICHHART JM, HOFFMANN JA, ROITSCH C, VAN DORSSELAER A
Eur. J. Biochem.
1991 : 196 735-742
Abstract

Article complet
Insect Immunity. Isolation from a coleopteran insect of a novel inducible antibacterial peptide and of new members of the insect defensin family.
BULET P, COCIANCICH S, DIMARCQ JL, LAMBERT J, REICHHART JM, HOFFMANN D, HETRU C, HOFFMANN JA
J. Biol. Chem.
1991 : 266 n° 36 24520-24525
Abstract

Article complet
Two-dimensional 1H-NMR study of recombinant insect defensin A in water. Resonance assignments, secondary structure and global folding.
BONMATIN JM, BONNAT JL, GALLET X, VOVELLE F, REICHHART JM, HOFFMANN JA, PTAK M
J. Biol. NMR
1991 : 2 235-256
Abstract

Article complet
Insect Immunity. Expression of the two major inducible antibacterial peptides, defensin and diptericin, in Phormia terranovae.
DIMARCQ JL, ZACHARY D, HOFFMANN JA, HOFFMANN D, REICHHART JM
EMBO J. 9
1990 : n° 8, 2507-2515
Abstract

Article complet
Synthesis of high specific activity [3H2-1,2]-7-dehydrocholesterol. Conversion to ecdysone in follicle cells of Locusta (Insects).
DOLLE F, KAPPLER C, HETRU C, ROUSSEAU B, COPPO M, LUU B, HOFFMANN JA
Tetrahedron 46
1990 : n°15 5305-5316
Abstract

Article complet
Insect Immunity. Characterization of a Drosophila cDNA encoding a novel member of the diptericin family of immune peptides and expression studies.
WICKER C, REICHHART JM, HOFFMANN D, HULTMARK D, SAMAKOVLIS C, HOFFMANN JA
J. Biol. Chem.
1990 : 265 n° 36 22493-22498
Abstract

Article complet
Insect immunity. Isolation from immune blood of the Dipteran Phormia terranovae of two novel antibacterial peptides with sequence homology to rabbit lung macrophage bactericidal peptides
LAMBERT J, KEPPI E, DIMARCQ JL, WICKER, C, REICHHART JM, DUNBAR B, LEPAGE P, VAN DORSSELAER A, HOFFMANN JA, FOTHERGILL J, HOFFMANN D
Proc. Nat. Acad. Sci.
1989 : USA 86 262-266
Abstract

Article complet
Enzymes involved in the biosynthesis of ecdysone. In "Ecdysone"
KAPPLER C, HETRU C, DURST F, HOFFMANN JA
J. Koolman Ed. Thieme Verlag-Berlin.
1989, pp 161-166
Abstract

Article complet
Allenic cholesteryl derivatives as inhibitors of ecdysone biosynthesis
BURGER A, ROUSSEL JP, HETRU C, HOFFMANN JA, B. LUU B
Tetrahedron
1989 : 45 155-164
Abstract

Article complet
Insect Immunity. Isolation of cDNA clones corresponding to diptericin, an inducible antibacterial peptide from Phormia terranovae (Diptera). Transcriptional profiles during immunization
REICHHART JM, ESSRICH M, DIMARCQ JL, HOFFMANN D, HOFFMANN JA, LAGUEUX M
Eur. J. Biochem.
1989 : 182 423-427
Abstract

Article complet
L-Canavanine incorporation into vitellogenin and macromolecular conformation.
ROSENTHAL GA, REICHHART JM, HOFFMANN JA
J. Biol. Chem.
1989 : 264, 13693-13696
Abstract

Article complet
Characterization of three hydroxylases involded in the final steps of biosynthesis of the steroid hormone ecdysone in Locusta migratoria (Insecta, Orthoptera)
Kappler C, Kabbouh M, Hetru C, Durst F and Hoffmann JA
J. Steroid Biochem.
1988 : 31, 891-898.
Abstract

Article complet
Insect immunity. Characterization of a family of novel inducible antibacterial proteins from immunized larvae of the dipteran Phormia terranovae and complete amino acid sequence of the predominant member, diptericin A
DIMARCQ JL, KEPPI E, DUNBAR B, LAMBERT J, REICHHART JM, HOFFMANN D, RANKINE SM, FOTHERGILL JE, HOFFMANN JA
Europ. J. Biochem.
1988 : 171 17-22
Abstract

Article complet
Study of the biosynthesis of ecdysone. Part IV. Synthesis of high specific activity (3H2-22,23)-2,22-dideoxyecdysone. Tissue distribution of the C-22 hydroxylase in Locusta migratoria
HAAG T, HETRU C, KAPPLER C, MOUSTIER AM, HOFFMANN JA. LUU B
Tetrahedron
1988 : 44 1397-1408
Abstract

Article complet
In vitro studies on potential selective and irreversible inhibitors of enzymes involved in the biosynthesis of ecdysone
BURGER A, ROUSSEL JP, COLOBERT F, KAPPLER C, HETRU C, LUU B, HOFFMANN JA
J. of Pesticide Biochem. and Physiol.
1987 : 29 197-208
Abstract

Article complet
Studies on the C-2 hydroxylation of 2-deoxyecdysone in Locusta migratoria
KAPPLER C, KABBOUH M, DURST F, HOFFMANN JA
Insect Biochem.
1986 : 16 25-32
Abstract

Article complet
Role of the follicle cells and the oocytes in ecdysone biosynthesis and esterification in vitellogenic females of Locusta migratoria.
KAPPLER C, GOLTZENÉ F, LAGUEUX M, HETRU C, HOFFMANN JA
Int. J. Invert. Reprod. Develop.
1986 : 9 17-34
Abstract

Article complet
Role of ecdysteroids in reproduction of Insects : a critical analysis. In "Advances in Invertebrate Reproduction"
HOFFMANN JA, LAGUEUX M, HETRU C, KAPPLER C, GOLTZENÉ F, LANOT R, THIEBOLD J
M. Porchet, J.C. Andries and A. Dhainaut-Eds. Elsevier, Amsterdam, New York.
1986, Oxford, pp 9-22
Abstract

Article complet
Ecdysone conjugates : isolation and identification. In "Methods in Enzymology".
HETRU C, LUU B, HOFFMANN JA
J.H. Law and H.C. Rilling Eds. Academic Press Orlando 111.
1985, part B 411-419
Abstract

Article complet
Recherches sur la conversion in vitro d'un précurseur de biosynthèse d'ecdysone, la 2,22,25-tridésoxyecdysone, par des tissus embryonnaires et larvaires de Locusta migratoria (Insecte Orthoptère)
MEISTER M, DIMARCQ JL, KAPPLER C, LAGUEUX M, HETRU C, LUU B, HOFFMANN JA

1985 : Paris 300 347-352
Abstract

Article complet
Conversion of radiolabelled ecdysone precursor, 2,22,25-tridésoxyecdysone, by embryonic and larval tissues of Locusta migratoria
MEISTER M, DIMARCQ JL, KAPPLER C, HETRU C, LAGUEUX M, LANOT R, LUU B, HOFFMANN JA
Molec. Cell. Endocrinol.
1985 : 41 27-44
Abstract

Article complet
Steroid hormones in Invertebrates.
HOFFMANN JA, HETRU C, LAGUEUX M, CHARLET M, HIRN M
Nova Acta Leopoldina Leipzig
1984 : 255 56-317
Abstract

Article complet
Ecdysteroids in ovaries and embryos of Locusta migratoria. Biosynthesis metabolism and mode of action of invertebrate hormones
LAGUEUX M, HOFFMANN JA, GOLTZENÉ F, KAPPLER C, TSOUPRAS G, HETRU C, LUU B.
J.A. Hoffmann and M. Porchet Eds.
Springer Verlag-Heidelberg, 1984, pp 168-180
Abstract

Article complet
Cycle de mue et ecdystéroïdes chez une sangsue, Hirudo medicinalis.
SAUBER F, REULAND M, BERCHTOLD JP, HETRU C, TSOUPRAS G, LUU B, MORITZ ME, HOFFMANN JA
C. R. Acad. Sci.
1983 : Paris 296 413-418
Abstract

Article complet
Conversion in vitro de 20-hydroxyecdysone en métabolites phosphorylés et acétylés par des complexes tube digestif-tubes de Malpighi de larves de Locusta migratoria
TSOUPRAS G, LUU B, HETRU C, MULLER JF, HOFFMANN JA
C. R. Acad. Sci.
1983 : Paris 296 77-80
Abstract

Article complet
Identification and metabolic fate of ovarian 22-adenosine-monophosphoric ester of 2-deoxyecdysone in ovaries and eggs of an insect, Locusta migratoria.
TSOUPRAS G, HETRU C, LUU B, CONSTANTIN E, LAGUEUX M, HOFFMANN JA
Tetrahedron Letters
1983 : 39 1789-1796
Abstract

Article complet
Synthesis of high specific activity (23,24)3H4-2-deoxyecdysone
HETRU C, NAKATANI Y, LUU B, HOFFMANN JA
Nouveau J. de Chimie
1983 : 27 587-591
Abstract

Article complet
Ecdysone. Endocrinology of Insects.
HOFFMANN JA, HETRU C.
R.G.H. Downer and H. Laufer
Eds. Alan R. Liss New York, 1983: pp 65-88
Abstract

Article complet
Fate of maternal conjugated ecdysteroids during embryonic development in Locusta migratoria
SALL C, TSOUPRAS G, KAPPLER C, LAGUEUX M, ZACHARY D, LUU B, HOFFMANN JA
J. Insect Physiol.
1983 : 29 491-507
Abstract

Article complet
The biosynthetic pathway of ecdysone : studies with vitellogenic ovaries of Locusta migratoria (Orthoptera)
HETRU C, KAPPLER C, HOFFMANN JA, NEARN R, LUU B, HORN DHS
Molec. Cell. Endocrinol.
1982 : 26 51-80
Abstract

Article complet
The major conjugates of ecdysteroids in young eggs and in embryos of Locusta migratoria
TSOUPRAS G, HETRU C, LUU B, LAGUEUX M, CONSTANTIN E, HOFFMANN JA
Tetrahedron Letters
1982 : 23 2045-2048
Abstract

Article complet
Ecdysteroids and ovarian development in the shore crab, Carcinus maenas.
LACHAISE, F, GOUDEAU M, HETRU C, KAPPLER C, HOFFMANN JA
Hoppe-Seyler's Z. Physiol. Chem.
1981 : 362 521-529
Abstract

Article complet
Ecdysone in reproductively competent female adults and in embryos of insects. In "Progress in Ecdysone Research".
HOFFMANN JA, LAGUEUX M, HETRU C, CHARLET M, GOLTZENE F
Hoffmann JA Ed. Elsevier, North-Holland.
1980, pp 431-465
Abstract

Article complet
Prothoracic gland activity and blood titres of ecdysone and ecdysterone during the last larval instar of Locusta migratoria
HIRN M, LAGUEUX M, HETRU C, HOFFMANN JA
J. Insect Physiol.
1979: 25 255-261
Abstract

Article complet
Ecdysone titre and metabolism in correlation to cuticulogenesis during embryonic development in Locusta migratoria
LAGUEUX M, HETRU C, GOLTZENE F, KAPPLER C, HOFFMANN JA
J. Insect Physiol.
1979: 25 709-723
Abstract

Article complet
Adult ovaries of Locusta migratoria contain the sequence of biosynthetic intermediate for ecdysone
LAGUEUX M, HETRU C, LUU B, HOFFMANN JA
Life Sciences
1978: 22 2141-2154
Abstract

Article complet




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