Immune-microenvironment interactions in health and disease
We investigate the functional relevance of immune cell - stromal microenvironment interaction in the context of the cutaneous immune system in health and disease.
The lymph node is composed of stromal cells (reticular fibroblastic cells, lymphatic and blood endothelial cells) that play a key role in organ formation and response to inflammation. In this context, we are interested in the endothelial-mesenchymal crosstalk in lymph node formation and immune cell homeostasis under steady state and inflammatory conditions. Learn more
Antigen presenting cells play a key role in controlling the balance between immunity and tolerance. We study this function in the context of arbovirus infections and lupus auto-immunity. Our team has highlighted the importance of human dermal CD14+ dendritic cells and macrophages in dengue virus infection and pathogenesis. In addition, we study the local activation of skin-resident memory T cells by cutaneous antigen presenting cells.
To translate our fundamental research to tangible applications, we generate complex human model systems. We are in the process of completing an immunocompetent human skin equivalent.