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Bianco |
Alberto |
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Tel. |
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33 388 417088 (+)
33 388 417029 |
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Fax |
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33 388 610680 |
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E_mail |
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Degree:
CR1 -CNRS |
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Position:
Associate Researcher |
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Research
Interests: -
Development of carbon nanomaterials (nanotubes and fullerenes) and their
use as new therapeutic vectors - Biological applications of functionalized carbon
nanotubes - Synthesis of peptidomimetics containing
fullero-amino acids as new ligands in immunotherapy - Solid-phase organic and combinatorial chemistry of
heterocyclic molecules -
Conformational characterization of solid supported molecules by HRMAS
NMR spectroscopy
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Available
positions: Any |
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Selection
of Recent Publication (2003-2006): Carbon
nanotubes Pantarotto,
D.; Hoebeke, J.; Graff, R.; Partidos, C. D.; Briand, J.-P.; Prato, M.; Bianco,
A. "Synthesis, Structural Characterization and Immunological
Properties of Carbon Nanotubes Functionalized with Peptides" J.
Am. Chem. Soc. 2003, 125, 6160-6164 Pantarotto,
D.; Partidos, C. D.; Hoebeke, J.; Brown, F.; Kramer, E.; Briand, J.-P.;
Muller, S.; Prato, M.; Bianco, A. "Immunization with
peptide-functionalized carbon nanotubes enhances virus-specific
neutralizing antibody responses" Chem. Biol. 2003, 10,
961-966 Pantarotto,
D.; Briand, J.-P.; Prato, M.; Bianco, A. "Translocation of
Bioactive Peptides Across Cell Membranes by Carbon Nanotubes" Chem.
Commun. 2004, 16-17 Pantarotto,
D.; Singh, R.; McCarthy, D.; Erhardt, M.; Briand, J.-P.; Prato, M.;
Kostarelos, K.; Bianco, A. “Functionalised carbon nanotubes for
plasmid DNA gene delivery” Angew. Chem. Int. Ed. 2004, 43,
5242-5246 Bianco,
A. “Carbon Nanotubes for the Delivery of Therapeutic Molecules” Expt.
Opin. Drug Deliv. 2004, 1, 57-65 Bianco,
A.; Kostarelos, K.; Partidos, C. D.; Prato, M. “Biomedical applications
of functionalised carbon nanotubes” Chem. Commun. 2005,
571-577 Bianco,
A.; Hoebeke, J.; Godefroy, S.; Chaloin, O.; Pantarotto, D.; Briand,
J.-P.; Muller, S.; Prato, M.; Partidos, C. D. “Cationic Carbon
Nanotubes Bind to CpG Oligodeoxynucleotides and Enhance Their
Immunostimulatory Properties” J. Am. Chem. Soc. 2005, 127,
58-59 Wu,
W.; Wieckowski, S.; Pastorin, G.; Benincasa, M.; Klumpp, C.; Briand,
J.-P.; Gennaro, R.; Prato, M.; Bianco, A. “Targeted Delivery of
Amphotericin B to Cells Using Functionalized Carbon Nanotubes” Angew.
Chem. Int. Ed. 2005, 44, 6358-6362 Tasis,
D.; Tagmatarchis, N.; Bianco, A.; Prato M. “Chemistry of Carbon
Nanotubes” Chem. Rev. 2006, 106, 1105-1136 Singh,
R.; Pantarotto, D.; Lacerda, L.; Pastorin G.; Klumpp, C.; Prato, M.; Bianco,
A.; Kostarelos, K. “Tissue Biodistribution and Blood Clearance
Rates of Intravenously Administered Carbon Nanotube Radiotracers” Proc.
Natl. Acad. Sci. USA 2006, 103, 3357-3362 Pastorin,
G.; Wu, W.; Wieckowski, S.; Kostarelos, K.; Briand, J.-P.; Prato, M.; Bianco,
A. “Double functionalisation of carbon nanotubes for multimodal
drug delivery” Chem. Commun. 2006, 1182-1184
Fullerene-based
amino acids and peptides Bianco,
A.; Pantarotto, D.; Hoebeke, J.; Briand, Prato, M.; "Solid-phase
synthesis and characterization of a novel fullerene-peptide derived from
histone H3" Org. Biomol. Chem. 2003, 1,
4141-4143 Pantarotto,
D.; Tagmatarchis, N.; Bianco, A.; Prato, M. "Synthesis and
Biological Properties of Fullerene-containing Amino Acids and
Peptides" MiniRev. Med. Chem. 2004, 4, 805-814 Bianco,
A. “Efficient solid-phase synthesis of fullero-peptides using
Merrifield strategy” Chem. Commun. 2005, 3174-3176.
HRMAS
NMR spectroscopy Lancelot,
N.; Elbayed, K.; Raya, J.; Piotto, M.; Briand, J.-P.; Formaggio, F.;
Toniolo, C.; Bianco, A. "Characterization of the 310-Helix
in Model Peptides by HRMAS NMR Spectroscopy" Chem. Eur. J. 2003,
9, 1317-1323 Rainaldi,
M.; Lancelot, N.; Elbayed, K.; Raya, J.; Piotto, M.; Briand, J.-P.;
Kaptein, B.; Broxterman, Q. B.; Berkessel, A.; Formaggio, F.; Toniolo,
C.; Bianco, A. "Conformational analysis by HRMAS NMR
spectroscopy of resin-bound homo-peptides from Ca-methyl-leucine" Org.
Biomol. Chem. 2003, 1, 1835-1837 Poschalko,
A.; Lancelot, N.; Marin, J.; Larras, V.; Limal, D.; Elbayed, K.; Raya,
J.; Piotto, M.; Briand, J.-P.; Guichard, G.; Bianco, A. "DEUSS:
a Perdeuterated Polyoxyethylene-based Resin for Improving HRMAS NMR
Study of Solid-supported Molecules" Chem. Eur. J. 2004,
10, 4532-4537
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Courses: International
School “Nanotubes” 3-15 July 2006, Cargèse, France Title:
“Biological applications of carbon nanotubes” Three-hour
course on the applications and impact on health of carbon nanotubes
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Keywords:
Carbon nanotubes, Fullerenes, Drug Delivery, Peptidomimetics,
Combinatorial Chemistry, HRMAS NMR Spectroscopy |
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