Jules Alphonse HOFFMANN
Born in Echternach (Luxembourg)
Married, two children (1970, 1974).
French citizenship.
Studies
Baccalauréat (General Certificate of Education), Luxembourg, 1960 (TB).
Doctorat ès Sciences Naturelles, Luxembourg, 1963 (B).
Doctorat d'Etat (Ph.D.), University of Strasbourg, 1969 (TH).
Functions
-Present:
Distinguished Class Research Director at CNRS and Group Leader (since 1990), Member of the Board of Administrators of CNRS.
President of the French National Academy of Sciences (since 2007).
-Previous:
Director of the CNRS Research Unit 9022 "Immune Response and Development in Insects" (1978-2005).
Director of the Institute of Molecular and Cellular Biology, CNRS, Strasbourg (1993-2005).
Post-doctoral training
Institut für Physiologische Chemie, Philipps Universität, Marburg an der Lahn.
Professor P. Karlson, 1973-1974.
Member of Academies
French National Academy of Sciences, Paris, 1992.
German Academy of Sciences Leopoldina, 1987.
Academia Europaea. 1993
Member of EMBO (European Molecular Biology Organization), 1995.
American Academy of Arts and Sciences, 2003.
Russian Academy of Sciences, 2006
Distinctions
Sandoz-Wander Price, 1978.
Pergamon Price, 1980.
Alexander von Humboldt Price, 1984.
Grand Prix Joannidès de l'Académie des Sciences, Paris, 1992.
Prix Lacassagne, Collège de France, 1996.Prix William B. Coley, Cancer Research Institute, USA, 2003
Robert Koch Prize for Immunology, 2004
Grand Prix de la Fondation pour la Recherche Médicale, 2004.
Dr honoris causa med., Munich, 2006
Organization of Meetings
Insect Physiology Congress, Strasbourg, 1975.
European Symposium on Ecdysone Research, Strasbourg, 1979.
International Meeting of CNRS on "Biosynthesis, Metabolism and Mode of Action of Invertebrate Hormones", Strasbourg, 1983.
Jacques Monod Conference on "Molecular Aspects of Invertebrate Hormones", Roscoff, 1990.
Six national Meetings on Ecdysone, Mont Ste-Odile, 1980-86.
EMBO Workshop on Insect Immunity, Mont Ste-Odile, September 6-13, 1992.
Roussel-Uclaf Round Table on "Phylogenetic Perspectives in Immunity : Host Defense in Insects", Congress Center of Versailles, Paris, September 21-22, 1993.
Co-Chair, First Gordon Research Conference, Ventura, California, 10-14 Mars 1997.
Chair, 2nd Gordon Research Conference on "Antimicrobial Peptides", Barga, Italy, 25-30 Avril 1999.
Organizer of the Workshop on Immunity, 40th Annual Drosophila Research Conference, Seattle, 24-28 Mars 1999.
Organizer of the Workshop on Immunity, 41th Annual Drosophila Research Conference, Pittsburgh, 2000.
Convenor, Session 13 "Insect Physiology, Neurosciences, Immunity and Cell Biology", XXI International Congress of Entomology, Iguassu Falls, Brazil, 21-26 August 2000.
Co-organizer of Keystone Symposium, Innate Immunity : Evolution and Link to Adaptative Immunity (with A. Ezekowitz and F. Kafatos), 2002.
Innate Immunity From Flies to Humans, French National Academy of Sciences, Paris, 2003.
Edition of Books
Progress in Ecdysone Research, Elsevier North Holland, 1980.
Biosynthesis, Metabolism and Mode of Action of Invertebrate Hormones, Springer-Verlag, 1985.
Cellular and Molecular Aspects of Insect Immunity, 34th Forum in Immunology, Research in Immunology 141, 895-960, Elsevier Institut Pasteur, Paris, 1990.
Phylogenetic Perspectives in Immunity : The Insect Host Defense, in Molecular Intelligence Unit, R.G. Landes, 1994.
Co-Editor (with A. Ezekowitz) on the Sections of Innate Immunity. Current Opinion in Immunology, Volumes 1995, 1996, 1998.
Innate Immunity, (editors J.Hoffmann, A. Ezekowitz), Humana Press 2002.
Co-Editor (with B. Beutler) of the Section of Innate Immunity, Current Opinion in Immunology, 2003.
Guest Editor of the Volume on : Primitive Immune Systems, Immunological Reviews, 2004.
International Contracts (Coordinator)
Human Frontiers in Science Program, Innate Immunity, 1995-1998.
Training and Mobility in Research, Programme Européen, 1996-2000.
National Institutes of Health, USA, Innate Immunity, 1998-2003.
Research Training Network, Programme Européen Malaria, 2000-2004.
National Institutes of Health, Antiviral Defenses, 2005-2009.
Publications
As of January 2007, 250 publications, of which the following 12 have been selected :
FRANC N, DIMARCQ JL, LAGUEUX M, HOFFMANN JA & EZEKOWITZ A (1996). Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells. Immunity. Vol 4 431-443
LEMAITRE B, NICOLAS E, MICHAUT L, REICHHART JM & HOFFMANN JA (1996). The dorsoventral regulatory gene cassette spaetzle/toll/cactus controls the potent antifungal response in Drosophila adults. Cell. Vol 86 973-983
FERRANDON D, JUNG AC, CRIQUI MC, LEMAITRE B, UTTENWEILER-JOSEPH S, MICHAUT L, REICHHART JM & HOFFMANN JA (1998). A GFP-drosomycin reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway. EMBO Journal. Vol17 1217-1227
DIMARCQ JL, BULET P, HETRU C & HOFFMANN JA (1998). Cysteine-rich antimicrobial peptides in invertebrates. Biopolymers (Peptide Science). Vol 47 465-477
HOFFMANN JA, KAFATOS FC, JANEWAY CA JR & EZEKOWITZ RAB (1999). Phylogenetic perspectives in innate immunity. Science. Vol284 1313-1318
RUTSCHMANN S, JUNG AC, ZHOU R, SILVERMAN N, HOFFMANN JA & FERRANDON D (2000). Role of Drosophila IKKgamma in a Toll-independent antibacterial immune response. Nature Immunology. Vol 1 342-347
TZOU P, OHRESSER S, FERRANDON D, CAPOVILLA M, REICHHART JM, LEMAITRE B, HOFFMANN JA & IMLER JL (2000). Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia. Immunity. Vol 13 737-748
GEORGEL, P., NAITZA S., KAPPLER, C., FERRANDON, D., ZACHARY, D., SWIMMER, C., KOPCZYNSKI, C., DUYK, G., REICHHART, J-M., AND HOFFMANN, J.A. ( 2001). Drosophila Immune Deficiency (IMD) is a Death Domain Protein that Activates Antibacterial Defence and Can Promote Apoptosis. Developmental Cell. Vol 1, 1-20, 503-514
MICHEL T, REICHHART JM, HOFFMANN JA & ROYET J. (2001). Drosophila Toll is activated by Gram-positive bacteria via a circulating peptidoglycan recognition protein. Nature. Vol 414, 756-759
GOTTAR M, GOBERT V, MICHEL T, BELVIN M, DUYK G, HOFFMANN JA, FERRANDON D, ROYET J, (2002). The Drosophila immune response against Gram-negative bacteria is médiated by a peptidoglycan recognition protein, Nature. Vol 416, 641-644
LIGOXYGAKIS P, PELTE N, HOFFMANN JA, REICHHART JM, (2002), Activation of Drosophila Toll during fungal infection by a novel blood serine protease, Science. Vol 297, 114-116
DOSTERT C, JOUANGUY E, IRVING P, TROXLER L, GALIANA-ARNOUX D, HETRU C, HOFFMANN JA, IMLER JL (2005). The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of Drosophila. Nature Immunology. Vol6, 946-953.
FROLET C, THOMA M, BLANDIN S, HOFFMANN JA, LEVASHINA EA (2006). Boosting NF-kB Dependent Basal Immunity of Anopheles gambiae Aborts Development of Plasmodium berghei. Immunity. Immunity. 2006 Oct;25(4):677-85.
GOTTAR M, GOBERT V, MASKEVITCH A, REICHHART JM, WANG C, BUTT T, BELVIN M, HOFFMANN JA, FERRANDON D (2006). Dual detection of fungal infections in Drosophila through recognition of microbial structures and sensing of virulence factors. Cell. In press.